RT article T1 Strategies to produce grapefruit-like citrus varieties with a low furanocoumarin content and distinctive flavonoid profiles A1 García-Lor, Andrés A1 Bermejo, Almudena A1 Morales, Julia A1 Hernández, María A1 Medina, Alejandro A1 Cuenca, José A1 Navarro, Luis A1 Aleza, Pablo K1 6,7-dihydroxybergamottin K1 Triploids K1 F30 Plant genetics and breeding K1 F60 Plant physiology and biochemistry K1 Q04 Food composition K1 Mandarins K1 Pummelos K1 Citrus K1 Antioxidants K1 Naringin K1 Breeding AB Pummelos and hybrids, such as grapefruits, have high furanocoumarin and low flavonoid contents. Furanocoumarins interact negatively with certain drugs, while flavonoids are antioxidant compounds with health benefits. To obtain new grapefruit-like varieties with low furanocoumarin and high flavonoid contents, diploid and triploid hybrid populations from crosses between diploid and tetraploid “Clemenules” clementine and diploid “Pink” pummelo were recovered and analyzed. With regard to furanocoumarins, triploids produce less bergapten, bergamottin and 6,7-DHB than diploids. Regarding flavonoids, triploids yielded more eriocitrin, narirutin, hesperidin and neohesperidin than diploids, whereas no differences were observed in neoeriocitrin and naringin. These results indicate that, the strategy to recover triploid hybrids by 4x × 2x crosses is more appropriate than the recovery of diploid hybrids by 2x × 2x crosses for obtaining grapefruit-like varieties of citrus with lower furanocoumarin and higher flavonoid contents. PB Frontiers Media SN 1664-462X YR 2021 FD 2021 LK http://hdl.handle.net/20.500.11939/7130 UL http://hdl.handle.net/20.500.11939/7130 LA en NO Garcia-Lor A, Bermejo A, Morales J, Hernández M, Medina A, Cuenca J, Navarro L and Aleza P (2021) Strategies to Produce Grapefruit-Like Citrus Varieties With a Low Furanocoumarin Content and Distinctive Flavonoid Profiles. Front. Plant Sci. 12:640512. DS MINDS@UW RD Feb 8, 2023