RT article
T1 The role of horizontal gene transfer in Staphylococcus aureus host adaptation
A1 Guinane, Caitriona M.
A1 Penadés, José R.
A1 Fitzgerald, J. Ross
K1 Host-adaptation
K1 Pathogenicity island
K1 L73  Animal diseases
K1 L70  Veterinary science and hygiene
K1 Staphylococcus
K1 Ruminants
K1 Humans
AB Staphylococcus aureus is an importanthuman pathogen that also causes economicallyimportant infections of livestock.In a recent paper, we employed apopulation genomic approach to investigatethe molecular basis of ruminant hostadaptation by S. aureus. The data suggestthat the common pathogenic cloneassociated with small ruminants originatedin humans but has since adaptedto its adopted host through a combinationof allelic diversification, gene lossand acquisition of mobile genetic elements.In particular, a new subfamilyof staphylococcal pathogenicity islands(SaPI) was identified encoding a novelvon Willebrand factor-binding protein(vWBP) with ruminant-specific coagulaseactivity. The wide distribution ofvWBP-encoding SaPIs among ruminantstrains implies an important role in hostadaptation.In the current article wesummarize the findings of the paper andcomment on the implications of the studyfor our understanding of the molecularbasis of bacterial host adaptation
PB Taylor & Francis
SN 2150-5594 (print)
YR 2011
FD 2011
LK http://hdl.handle.net/20.500.11939/6902
UL http://hdl.handle.net/20.500.11939/6902
LA en
NO Guinane, C. M., Penadés, J. R., & Fitzgerald, J. R. (2011). The role of horizontal gene transfer in Staphylococcus aureus host adaptation. Virulence, 2(3), 241-243.
DS MINDS@UW
RD Aug 10, 2022