RT article
T1 A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
A1 Bacigalupe, Rodrigo
A1 Tormo-Mas, María A.
A1 Penadés, José R.
A1 Fitzgerald, J. Ross
K1 L73  Animal diseases
K1 Pathogenic bacteria
K1 Infectious diseases
AB While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches,leading to the emergence of new clones that are a threat tohuman and animal health. However, the bacterial traits thatunderpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations areinfluenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting thecapacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigatethe ability of themultihost pathogen Staphylococcus aureus to adapt to new species under continuous populationbottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift andsweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of somebacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.
PB AAAS (American Asociation for the Advancement of Science)
SN 2375-2548
YR 2019
FD 2019
LK http://hdl.handle.net/20.500.11939/6473
UL http://hdl.handle.net/20.500.11939/6473
LA en
NO Bacigalupe, R., Tormo-Mas, M. Á., Penadés, J. R., & Fitzgerald, J. R. (2019). A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science advances, 5(11), eaax0063.
DS MINDS@UW
RD Dec 4, 2023