RT article T1 Technical Note: Effect of Handling on Stress-Induced Hyperthermia in Adult Rabbits A1 Olivas, Irene A1 Villagrá, Arantxa AB Animals perceive humans as a threat, therefore handling could cause stress reactions and fear in rabbits. Stress induced hyperthermia (SIN) is a physiological response produced when a stressful situation takes place and is supposed to occur in rabbits. In this work, the SIH response is assessed when different groups of rabbits (young males, nulliparous does and multiparous does) are handled. A benzodiazepine (Midazolam (R)) was administered to half of the animals to assess handling response also under drug effects. Rectal temperature was not increased by handling in male rabbits and multiparous does, whereas nulliparous females showed presented SIH after 30 min of handling. In addition, Midazolam (R) has been revealed as useful for pharmacological validation of SIH after 25 min from injection. SN 1257-5011 YR 2013 FD 2013 LK http://hdl.handle.net/20.500.11939/4234 UL http://hdl.handle.net/20.500.11939/4234 LA en NO Olivas, I., Villagra, A. (2013). Technical Note: Effect of Handling on Stress-Induced Hyperthermia in Adult Rabbits. World Rabbit Science, 21(1), 41-44. DS MINDS@UW RD Nov 30, 2023