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dc.contributor.authorRíos, Gabino
dc.contributor.authorCabedo-López, Marc
dc.contributor.authorRull, Baltasar
dc.contributor.authorYenush, Lynne
dc.contributor.authorSerrano, Ramón
dc.contributor.authorMulet, José M.
dc.date.accessioned2020-06-03T15:40:25Z
dc.date.available2020-06-03T15:40:25Z
dc.date.issued2013es
dc.identifier.citationRíos, G., Cabedo, M., Rull, B., Yenush, L., Serrano, R., & Mulet, J. M. (2013). Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response. FEMS yeast research, 13(1), 97-106.es
dc.identifier.issn1567-1364
dc.identifier.issn1567-1356
dc.identifier.urihttp://hdl.handle.net/20.500.11939/6495
dc.description.abstractWe have identified QDR2 in a screening for genes able to confer tolerance to sodium and/or lithium stress upon overexpression. Qdr2 is a multidrug transporter of the major facilitator superfamily, originally described for its ability to transport the antimalarial drug quinidine and the herbicide barban. To identify its physiological substrate, we have screened for phenotypes dependent on QDR2 and found that Qdr2 is able to transport monovalent and divalent cations with poor selectivity, as shown by growth tests and the determination of internal cation content. Moreover, strains overexpressing or lacking QDR2 also exhibit phenotypes when reactive oxygen species- producing agents, such as hydrogen peroxide or menadione were added to the growth medium. We have also found that the presence of copper and hydrogen peroxide repress the expression of QDR2. In addition, the copper uptake of a qdr2 mutant strain is similar to a wild type, but the extrusion is clearly impaired. Based on our results, we propose that free divalent copper is the main physiological substrate of Qdr2. As copper is a substrate for several redox reactions that occur within the cytoplasm, its function in copper homeostasis explains its role in the oxidative stress response.es
dc.language.isoenes
dc.publisherOxford University Presses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectIon transportes
dc.subjectCopper homeostasises
dc.titleRole of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress responsees
dc.typearticlees
dc.authorAddressInstituto Valenciano de Investigaciones Agrarias (IVIA), Carretera CV-315, Km. 10’7, 46113 Moncada (Valencia), Españaes
dc.entidadIVIACentro de Citricultura y Producción Vegetales
dc.identifier.doi10.1111/1567-1364.12013es
dc.identifier.urlhttps://academic.oup.com/femsyr/article/13/1/97/545699es
dc.journal.issueNumber1es
dc.journal.titleFEMS Yeast Researches
dc.journal.volumeNumber13es
dc.page.final106es
dc.page.initial97es
dc.source.typeelectronicoes
dc.subject.agrisF62 Plant physiology - Growth and developmentes
dc.subject.agrovocOxidative stresses
dc.type.hasVersionacceptedVersiones


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