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dc.contributor.authorBacigalupe, Rodrigo
dc.contributor.authorTormo-Mas, María A.
dc.contributor.authorPenadés, José R.
dc.contributor.authorFitzgerald, J. Ross
dc.date.accessioned2020-05-27T08:58:17Z
dc.date.available2020-05-27T08:58:17Z
dc.date.issued2019
dc.identifier.citationBacigalupe, R., Tormo-Mas, M. Á., Penadés, J. R., & Fitzgerald, J. R. (2019). A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science advances, 5(11), eaax0063.
dc.identifier.issn2375-2548
dc.identifier.urihttp://hdl.handle.net/20.500.11939/6473
dc.description.abstractWhile many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat tohuman and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of themultihost pathogen Staphylococcus aureus to adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.es
dc.language.isoenes
dc.publisherAAAS (American Asociation for the Advancement of Science)es
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleA multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host speciesen
dc.typearticlees
dc.authorAddressInstituto Valenciano de Investigaciones Agrarias (IVIA), Carretera CV-315, Km. 10’7, 46113 Moncada (Valencia), Españaes
dc.entidadIVIACentro de Tecnología Animales
dc.identifier.doi10.1126/sciadv.aax0063es
dc.identifier.urlhttps://advances.sciencemag.org/content/5/11/eaax0063es
dc.journal.issueNumber11es
dc.journal.titleScience Advanceses
dc.journal.volumeNumber5es
dc.page.finaleaax0063es
dc.page.initialeaax0063es
dc.source.typeelectronicoes
dc.subject.agrisL73 Animal diseaseses
dc.subject.agrovocPathogenic bacteriaes
dc.subject.agrovocInfectious diseaseses
dc.type.hasVersionpublishedVersiones


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España