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dc.contributor.authorAncillo, Gema
dc.contributor.authorGadea, Jose
dc.contributor.authorForment, Javier
dc.contributor.authorGuerri, José
dc.contributor.authorNavarro, Luis
dc.identifier.citationAncillo, G., Gadea, J., Forment, J., Guerri, J., Navarro, L. (2007). Class prediction of closely related plant varieties using gene expression profiling. Journal of experimental botany, 58(8), 1927-1933.
dc.description.abstractIn recent years, class prediction experiments have been largely developed in cancer research with the aim of classifying unknown samples by examining their expression signature. In natural populations, a significant component of gene expression variability is also heritable. Citrus species are an ideal model to accomplish the study of these questions in plants, due to the existence of varieties derived from somatic mutations that are likely to differ from each other by one or a few point mutations but are phenotypically indistinguishable at early vegetative stages. The small genetic variability existing among these varieties makes molecular markers ineffective in distinguishing genotypes within a particular species. Gene expression profiles have been used to predict mandarin clementine varieties (Citrus clementina, Hort. ex Tan.) by means of two independent supervised learning algorithms: Support Vector Machines and Prediction Analysis of Microarrays. The results show that transcriptional variation is variety-dependent in citrus, and supervised clustering methods may correctly assign blind samples to varieties when both training and test samples are under the same experimental conditions.
dc.titleClass prediction of closely related plant varieties using gene expression profiling
dc.authorAddressInstituto Valenciano de Investigaciones Agrarias (IVIA), Carretera CV-315, Km. 10’7, 46113 Moncada (Valencia), Españaes
dc.entidadIVIACentro de Protección Vegetal y Biotecnología
dc.journal.titleJournal of experimental botany

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