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dc.contributor.authorTormo-Mas, María A.
dc.contributor.authorMir, Ignacio
dc.contributor.authorShrestha, Archana
dc.contributor.authorTallent, Sandra M.
dc.contributor.authorCampoy, Susana
dc.contributor.authorLasa, Inigo
dc.contributor.authorBarbe, Jordi
dc.contributor.authorNovick, Richard P.
dc.contributor.authorChristie, Gail E.
dc.contributor.authorPenadés, José R.
dc.date.accessioned2017-06-01T10:09:49Z
dc.date.available2017-06-01T10:09:49Z
dc.date.issued2010
dc.identifier.citationTormo-Mas,María A.; Mir, I., Shrestha, Archana, Tallent, Sandra M., Campoy, S., Lasa, Inigo, Barbe, Jordi, Novick, Richard P., Christie, Gail E., Penades, J.R. (2010). Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature, 465(7299), 779-U7.
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/20.500.11939/4306
dc.description.abstractStaphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of similar to 15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently encapsidated in phage-like infectious particles, leading to extremely high frequencies of intra-as well as intergeneric transfer(1-3). In the absence of helper phage lytic growth, the island is maintained in a quiescent prophage-like state by a global repressor, Stl, which controls expression of most of the SaPI genes(4). Here we show that SaPI derepression is effected by a specific, non-essential phage protein that binds to Stl, disrupting the Stl-DNA complex and thereby initiating the excision-replication-packaging cycle of the island. Because SaPIs require phage proteins to be packaged(5,6), this strategy assures that SaPIs will be transferred once induced. Several different SaPIs are induced by helper phage 80 alpha and, in each case, the SaPI commandeers a different non-essential phage protein for its derepression. The highly specific interactions between different SaPI repressors and helper-phage-encoded anti-repressors represent a remarkable evolutionary adaptation involved in pathogenicity island mobilization.
dc.language.isoen
dc.titleMoonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands
dc.typearticle
dc.authorAddressInstituto Valenciano de Investigaciones Agrarias (IVIA), Carretera CV-315, Km. 10’7, 46113 Moncada (Valencia), Españaes
dc.date.issuedFreeFormJUN 10 2010
dc.entidadIVIACentro de Tecnología Animal
dc.identifier.doi10.1038/nature09065
dc.journal.abbreviatedTitleNature
dc.journal.issueNumber7299
dc.journal.titleNature
dc.journal.volumeNumber465
dc.page.finalU7
dc.page.initial779
dc.rights.accessRightsopenAccess
dc.source.typeImpreso
dc.type.hasVersionacceptedVersion


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